May Vendor Sponsor - Thermo Fisher - Dave Clark - www.thermofisher.com

 

Main Speaker: Mr. William Evans - Process Technical Service Specialist - Tosoh Bioscience LLC - King of Prussia, PA

Title:  Characterization of a Novel Cation Exchange Resin for the Intermediate Purification of Monoclonal Antibodies

Abstract:  Monoclonal antibodies are the largest class of approved biopharmaceutical molecules. Downstream purification processes for monoclonal antibodies often employ a cation exchange chromatography step to remove aggregated proteins. In this presentation, we examine the characterization of a novel cation exchange resin for the removal of aggregates from monoclonal antibody preparations. Performance of the resin against traditional cation exchangers is examined, and case studies are performed examining the performance of the resin in both bind-and-elute and flow-through chromatography modes. Separations are optimized with multivariable analysis (DoE) techniques.

Bio:  Bill obtained his bachelor’s degree in Cell Biology/Biochemistry from Bucknell University. He continued his studies at M.I.T. where he earned a master’s degree in Biology. Prior to joining Tosoh Bioscience LLC in 2014, Bill had experience in analytical method development at Neose Technologies, in vitro assay development and protein purification at Locus Pharmaceuticals, and viral clearance at Charles River Laboratories. Bill joined Tosoh Bioscience LLC (Tosoh) in March 2014 as a process technical service specialist. His research includes developing applications using the comprehensive line of process media from Tosoh. He also assists customers with a variety of process chromatography technical issues. 

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Graduate Student Speaker: Wanted - If you know of a student that would like to make a 20 minute presentation to our group please let us know!

Title: TBD  Abstract: TBD